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Objective:To explore the management system of Collaborative Innovation in military medical universities from the strategy perspective of deep integration of civil-military.Methods:By analyzing and comparing the differences between medical and engineering disciplines, as well as differences between military and local academies, this paper discusses the advantages, disadvantages and development paths of promoting the collaborative innovation of civil-military in military medical universities.Results:Based on the current situation of integration of civil-military and the characteristics of medical research, military medical university has advantages in promoting the deep integration of civil-military, however, there are still some bottleneck problems in the development of collaborative innovation, so it is necessary to establish and improve the regional system, operation system and guarantee system of the collaborative innovation of civil-military in terms of innovation director, innovation resources and innovation environment.Conclusions:By improving the system of collaborative innovation of civil-military, it helps to form a regional innovation chain of civil-military integration, promotes the construction of platform and technological development for military medical university.
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Objective@#To explore the mechanism of Xuebijing injection in the treatment of acute paraquat poisoning by means of studying the expression of TNF-alpha, NF-kappa B, Caspase-3 and the changes of cell apoptosis rate detected by TUNEL in the lung tissue of acute paraquat-induced rats.@*Methods@#On the base of random number table, 126 Wister rats weighing 220 g to 270 g were divided into 3 groups: (1) Control group: 42 rats, (2) Poisoned group: 42 rats, (3) Treatment group: 42 rats. On 1st、3rd、7th、14th、21st、28th、and 35th day, six rats from each group were anaesthetized by intraperitoneal injection of chloral hydrate. To cut the chest and take the lung tissue samples. The expression levels of Tumor Necrosis Factor-alpha, Nuclear Factor-kappa B and Caspase-3 protein in lung tissue were detected by immunohistochemical staining, as well as apoptotic cell rate was detected by TUNEL staining.@*Results@#The expression levels of Tumor Necrosis Factor-alpha, Nuclear Factor-kappa B, Caspase-3 protein and TUNEL staining in the lung tissue of the poisoned group was significantly higher than that of the control group (P<0.05) . Compared with the poisoned group, the expression of TNF-alpha, NF-kappa B, Caspase-3 and TUNEL in treatment group decreased significantly (P<0.05) , but they were still higher than those of the control group, and the difference was statistically significant compared with the control group (P<0.05) .@*Conclusion@#Apoptosis and TNF-alpha, NF-kappa B and Caspase-3 play an important role in lung injury of paraquat-induced rats. Xuebijing injection can inhibit the expression of TNF-alpha, NF-kappa B, Caspase-3 in lung tissue, reduce the apoptosis rate and alleviate the damage of lung tissue in paraquat-poisoning rats.
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Objective To study the frequency range of "Ling Six Sounds"(LST) in Standard Chinese (SC)and compare with American English (AE) version,and to obtain reference for conducting the "Ling Six Sounds" test in the mainland of China.Methods A total of 60 adults (30 females,30 males) with normal hearing speaking Standard Chinese in their ordinary conversation were recruited to record [m],[u],[a],[i],[(s)],[s] and syllables of [mo],[(s)(l)],[s(l)] (/mo/,/shi/,/si/).This study extracted first formant (F1) and second formant (F2) of vowels and center of gravity of consonants to analyze.Results The frequency range of "Ling Six Sounds" in Standard Chinese was approximately from 200 to 11 000 Hz which was broader than American English.The six sounds of SC showed greatly diverse frequency distributions,especially the sibilants [(s)],[s].There were significant differences between genders (P＜0.05) and the frequency of isolated consonants was slightly higher than consonants in syllables which also had significant differences (P＜0.05) except [m].Conclusion The six sounds in AE and SC version show greatly diverse frequency distributions.It's necessary to pay attention to the manner of articulation when administer the test in consonants and acquire an adaption version of LST,eg adding tone tests and investigating the frequency range of LST in dialectal areas in China.
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Objective Analyze the patterns of output of the papers by NSFC funding project,and understand the impact of NSFC on SCI paper publication.Methods The SCI papers were retrieved by the web of science,the license number of the fund grants institution was matched with the approval number of NSFC,to conduct the descriptive and univariate analysis.Results Since 2011,the labeling number and frequency of NSFC projects in SCI papers had been increased annually.Except for the projects completed in 2011 and 2012,most funding labeling were marked in the project-concluding year.Among the SCI papers published in 2015,the average labeling number and rank of projects funded for more than RMB 900,000 was higher than the low-budget items,also,the four-year projects were higher than the three-year project.Conclusions The role of the NSFC in boosting the publication of SCI papers has been increasing year by year,increasing annually before the projects concluding year,while decreasing after the completion.Higher funding and longer project period have relatively higher impact.
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Objective To investigate the clinicopathological features,treatment and prognosis of leiomyomatosis peritonealis disseminata (LPD).Methods A total of 10 patients suffered from LPD after laparoscopic uterine myomectomy were collected in the First Affiliated Hospital of Zhengzhou University from September 2012 to September 2016,and all clinical database were retrospectively analyzed.Results (1)Clinical features:the age of 10 cases was 25-50 years old,and 8 cases of them were in child-bearing age,while 2 cases were in perimenopausal period.Of 10 cases,2 cases manifested as discontinuous lower abdominal pain,and the other cases were seen the doctor for the examinations found tumors of pelvis or abdomen.All 10 cases had a history of laparoscopic uterine myomectomy under went power morcellation with an average of (4.0±2.2) years (range 1.3 to 8.1 years),2 cases of them had a history of oral hormone treatment after the first myoma morcellation.(2) Treatment methods and postoperative pathologic diagnosis:during intraoperative exploration,LPD nodules were most distributed in Douglas pouch (10 cases),and next in mesentery (7 cases),abdominal peritoneum (6 cases) and omentum majus (4 cases),etc.Seven of the 8 cases of child-bearing age were performed laparoscopic LPD nodules removal,1 case gone combined with laparotomy and resecting LPD nodules;2 cases in perimenopausal period done laparotomy oophorotomy and resected all LPD nodules and omentum.(3) Postoperative relapse and reproductive outcomes:the follow-up time of all cases was 2.8 years,and no recurrence was found during the follow-up period;2 cases had natural conception and term vaginal birth during the follow-up period.Conclusions LPD is mainly related to iatrogenic planting and spreading,which is a benign disease and characterized by multiple smooth muscle nodules throughout abdominopelvic cavity,and the nodules of LPD is commonly located in Douglas pouch,mesenteric and omentaum majus,etc.The preferred method of LPD should be individual operative treatment according to different situations,and in which patients may be have better prognosis.
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Based on the analysis of the management of Director 's target responsibility system in China Academy of Chinese Medical Sciences these years, the methods and experience were introduced in this paper. How to further improve the management was also discussed, providing a certain reference for the target responsibility system management of scientific research institutes.
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Aging is associated with declines of the muscular strength and cardiorespiratory functions, resulting in an impaired capacity to perform daily activities. Frailty is a clinical geriatric syndrome characterized by decreases in the biological functional reserve and resis-tance to stressors, which puts older individuals at special risk of disability. To counteract the muscular strength and cardiorespiratory func-tions declines associated with aging, as well as to prevent and treat the frailty syndrome, the strength and endurance training seems to be an effective strategy to improve muscular strength and endurance performance. This article reviewed the exercise prescription in health and frail elderly subjects according to the current situation of the researches about muscular strength and cardiorespiratory function training. Based on the results found, for the healthy older adults, strength training should be performed at moderate-to high-intensity (60%-80%of 1 RM ), and moderate volume (2-3 sets per exercise, 2-3 times/week ). Also, endurance training should be performed at moderate-to high-in-tensity (60%-85% of VO2max), and moderat volume (25-40 min). The frail older adults should exercise 2-3 times a week, for 45-60 min. Strength, endurance, flexibility, and balance training components should be incorporated, and strength and balance training should be empha-sized.
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The historical contributions of traditional Chinese medicine (TCM) was discussed in this paper. Firstly, TCM is the unique medical science created by working people of China. Secondly, TCM contributes greatly to the prosperity of the nation. Thirdly, TCM shows positive influences on promoting the process of world civilization. Finally, TCM is the outstanding representative of traditional Chinese culture. In the way, it guided people to treat TCM in an objective way, to make people follow its own development rule and to promote its inheritance and innovation.
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Objective:To detect the expression of ALDH1 and ABCG2 in the specimens from different levels of cervical lesions.Methods:Use SP immunohistochemistry to detect the expression of ALDH1 and ABCG2 in 76 cases of cervical squamous cancers,52 cases of HSIL,and 37 cases of chronic cervicitis tissues,and analyze the results.Results:①The positive expression rates of ALDH1 and ABCG2 in chronic cervicitis tissues were 5.41％ (2/37) and 8.11％ (3/37),in HSIL tissues were 23.08％ (12/52) and 28.85％ (15/52),and in cervical cancers tissues were 53.95％ (41/76) and 61.84％ (47/76),respectively.The positive expression rates in cervical cancers tissues were significantly higher than in HSIL and Cc hronic cervicitis tissues,(P ＜ 0.05).②The positive expression of ALDH1 in cervical cancer tissues had correlation with tumor grade and lymphnode metastasis (P ＜0.05),while the positive expression of ABCG2 in cervical cancer tissues had correlation with tumor grade,clinical stage and lymph-node metastasis(P ＜0.05).③The expressions of ALDH1 and ARCG2 in cervical cancer were positive relative(r =0.535,P ＜ 0.05).Conclusions:The increased expressions of ALDH1 and ABCG2 in cervical squamous cancer may play a role in the occurrence,development and metastasis of cervical squamous cell carcinoma.ALDH1 and ABCG2 may have synergistic effect in occurrence of cervical cancer.
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Base on literature analysis, the paper summarized that the five core principles of the traditional Chinese medicine academic development included that the practice is the source of traditional Chinese medicine development, the culture is the foundation of traditional Chinese medicine development, the inheritance is the basic approach of traditional Chinese medicine development, the classics is the important carrier of traditional Chinese medicine development, and the innovation is the power of traditional Chinese medicine development.
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Base on literature analysis, the paper summarized that the five core principles of the traditional Chinese medicine academic development included that the practice is the source of traditional Chinese medicine development, the culture is the foundation of traditional Chinese medicine development, the inheritance is the basic approach of traditional Chinese medicine development, the classics is the important carrier of traditional Chinese medicine development, and the innovation is the power of traditional Chinese medicine development.
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<p><b>OBJECTIVE</b>To investigate the expressions of P38 mitogen-activated protein kinases (P38 MAPK), JNK mitogen-activated protein kinases (JNK MAPK) and the therapeutical effects of melatonin in the renal tissue of acute acuteparaquat-induced rats.</p><p><b>METHODS</b>Seventy-eight healthy adult Sprague-Dawley (SD) rats (39 male, 39 female) were randomly divided into three groups: (1) Control group (group A): 6 rats, (2) Poisoned group (group B): 36 rats, (3) Therapeutical group (group C): 36 rats. At 1, 3, 5, 7, 10 and 14 days after poisoning, six rats in Group B and group C were used to assess renal pathological changes and the expression of P38 MAPK, JNK MAPK in kidney were evaluated by immunohistochemistry.</p><p><b>RESULTS</b>Compared with control group, the expression of P38MAPK in renal tissue of poisoned group significantly rose at the first day, reached the peak at the 10th day and afterwards decreased slowly. Expression of JNK MAPK reached the peak at the first day, and kept at relatively high levels up to the 14th day. Melatonin weakened markedly the expressions of P38 MAPK and JNK MAPK in renal tissue of acute acuteparaquat-induced rats.</p><p><b>CONCLUSION</b>P38 MAPK and JNK MAPK play an important role in renal injury of acute paraquat -poisoning rats. Melatonin takes a significant effect on the activation of them.</p>
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Animals , Female , Male , Rats , JNK Mitogen-Activated Protein Kinases , Metabolism , Kidney , Metabolism , Melatonin , Therapeutic Uses , Paraquat , Poisoning , Rats, Sprague-Dawley , p38 Mitogen-Activated Protein Kinases , MetabolismABSTRACT
Objective To evaluate the prevention and treatment effect of butylphthalide injection in delayed encephalopathy after severe carbon monoxide poisoning(DESCMP).Methods One hundred and fiftyeight cases with severe carbon monoxide poisoning (SCMP) were randomly assigned to 2 groups.Observation group (n =83), butylphthalide treatment when SCMP was diagnosed;Control group (n =75), with no butylphthalide therapy.Incidence rate in 3 month, drug amount and the clinical effects of butylphthalide were observed.Results Observation group occurred 5 DEACMP, with the incidence rate of 6.58％, and control group occurred 14 cases,with the incidence rate of 18.67％ ,significant difference was observed in two groups(x2 =154.204,P＜0.05).There were also significant differences in the glasgow coma scale(14.00±1.89 vs.13.00 ±3.30,t =1.780, P＜ 0.05) and mini-mental state examination (26.20± 2.89 vs.19.57 ± 7.12, t =2.003, P＜0.05) between the two groups.Conclusion Early treatment with butylphthalide can decrease the incidence rate of DEACMP.
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BACKGROUND:Posterior capsulotomy with Nd-YAG laser is the main method in clinic for the treatment of after-cataract, but it often damages the intraocular lens during the treatment. OBJECTIVE:To research the effect of Nd-YAG laser damage on the intraocular lens optical properties based on the laboratory testing. METHODS:Ten hydrophobic acrylic intraocular lenses were col ected as the test samples, and then Nd-YAG laser with the pulse energy of 5.0 mJ was used for 50 single-pulse laser shooting on the center of a circle with the diameter of 3 mm on the back surface of each sample. The shapes of the damaged area on the samples were observed under scanning electron microscope after laser shooting. Optical analyzer was used to test the average optical power and optical power distribution. RESUTLS AND CONCLUSION:The intraocular lenses were observed under scanning electron microscope under 40 times and 1 000 times enlargement and showed that there was circle-like depression with the diameter about 50μm on the back surface of the intraocular lenses, and there was protruding around the depression. Intraocular lens optical analyzer test results showed that there was no significant change in the average optical power of intraocular lenses after laser damage, but the optical power distribution was changed significantly. In the center of the circle with the diameter of 3 mm, the optical power showed annular distribution radiating to the surrounding tissue with the center of circle-like depression area. The Nd-YAG laser damage has less effect on the optical power, but has great effect on the optical power distribution of intraocular lenses.
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Based on hospital development cycle and the core rigidities theory,the authors made a strategic analysis on the building of research-oriented hospital of the Eastern Hepatobiliary Surgery Hospital.They put forward that building a research-oriented hospital is key to exceeding the core rigidities of the hospital and promoting core competence.In their practice,they developed the model featuring innovation culture as the leader,hospital-institute in one as the pattern,composite talents as the core,integrated innovation as the mechanism,and high-level medical cooperation as promoter.
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The paper analyzed the experiences of clinical subjects development at hospitals of Capital Medical University.On this basis,the authors raised such development suggestions as further improvement of the management systems,progressive affiliation mechanism,information platform,and better performance appraisal mechanism,for the purposes of empowering the standard and strength of clinical subjects of the hospitals.
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MicroRNA (miRNA) is a class of endogenous,single-stranded non-coding small RNA that contains 21 to 23 nucleotides and is widely distributed in eucaryon,miRNA plays an important regulatory role in cell proliferation,apoptosis,growth and development through the regulation of gene translation after transcription and expression,miRNA has a close relationship with pathogenesis and development of hepatocellular carcinoma.And in this process,part of miRNA acts as oncogenes or tumor suppressor genes.A number of miRNA,such as miR-30d,miR-221,miR-222 and miR-101,had been found to express abnormally in hepatoeellular carcinoma.Here we summarize the related progress in research of miRNA and hepatocellular carcinoma.
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Objective To observe the effects of touching combined with inhalation of atomized traditional Chinese medicine in the treatment of recurrent respiratory tract infection.Methods 79 cases were selected according to the inclusion criteria from 105 repeated respiratory traction infection children who were treated in this hospital from September 2008 to August 2009.These cases were randomly recruited into a treatment group(40 cases)and a control group(39 cases).The control group was given conventional therapy at the period of onset,and intensive care at convalescence stage,avoiding cross infection.On this basis.the treatment group was treated with toughing plus inhalation of atomized traditional Chinese medicine at the period of onset.The frequency of respiratory tract infection,duration,appetite,and the condition of sleep were observed after one year's treatment.Results The total effective rate was 92.5%and 67%in the treatment group and the control group respectively,showing significant difference(χ~2=20.16,P＜0.05).Conclusion Touching combined wim inhalation of atomized traditional Chinese medicine is effective in treating recurrent respiratory tract infections in children.
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Objective To study the clinical,imaging and pathological features of hepatic angiomyolipoma,and to investigate methods in improving the preoperative diagnosis rate.Methods The imaging features and treatment experience of 73 patients with hepatic angiomyolipoma who had been admitted to the Eastern Hepatobiliary Surgery Hospital from 2000 to 2007 were retrospectively analyzed.All patients were classified according to the imaging features and corresponding treatments were applied.Results Of all patients,7 were diagnosed preoperatively.The diagnostic rate of B ultrasound,computed tomography and magnetic resonance imaging were 0,13%(7/56)and 6% (2/33),respectively.According to the results of imaging examination,6 patients were with the type of hemangioma,17 with the type of lipoma,4 with the type of leiomyoma and 46 with mixed type.One patient was treated by radiofrequeney ablation and 72 by surgical resection.Twenty-four patients were presented with pulmonary infection,pleural effusion,ascites or slight hepatic dysfunction.Postoperative immunohistochemical assay demonstrated that HMB45 had the highest positive expression rate,then followed by smooth muscle actin,vimentin,proliferating cell nuclear antigen,CD34,polyclonal carcinoembryonic antigen,CD18,CD19 and p53.One patient died of postoperative tumor recurrence.Conclusions Hepatic angiomyolipoma is easy to be misdiagnosed,while imaging classification is helpful in the diagnosis.Surgical resection is beneficial to patients with hepatic angiomyolipoma.
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Objective To explore the safety and efficacy of hepatic resection with selective hepatic vascular exclusion(SHVE). Methods SHVE was used in 246 consecutive patients undergoing major or complex liver resection in our center. Preoperative demographic and clinical data,details of the surgical procedure, pathologic diagnosis, postoperative course and complications were collected and analy zed. Results From January 2000 to July 2007, liver resections were performed IJnder SHVE in 246 patients; total SHVE, right partial SHVE and left partial SHVE in 145, 54 and 47 patients, respectively. SHVE was converted to total hepatic vascular exclusion(THVE)in 3 patients to repair the wall of inferior vena cava(IVC). Hemodynamic tolerance to SHVE was excellent, only with a slight increase in systemic and pulmonary vascular resistance during clamping.There were no deaths. and the morbidity was 24.8%.The mean leyth of hospital stay was 9.6 days(range 8-18) .Conclusion Our study showed that SHVE is a safe and effective procedurei and it is applicable to liver tumors near but not invade the inferior vena cava.